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A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status
Published on: October 20, 2016
Cerebrospinal fluid apolipoprotein E concentration decreases after seizure
Liang Wang1, Yanbing Han, Dan Chen
1Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, 1 You Yi Road, Chongqing 400016, China.
Seizure
|January 23, 2010
Summary
Cerebrospinal fluid apolipoprotein E (CSF-apoE) levels are lower in epilepsy patients compared to controls. These levels also vary based on gender, epilepsy type, and seizure characteristics.
Area of Science:
- Neurology
- Biochemistry
Background:
- Previous research linked apolipoprotein E (apoE) gene polymorphism to earlier onset of temporal lobe epilepsy.
- No prior studies investigated apolipoprotein E (apoE) levels in cerebrospinal fluid (CSF) of epilepsy patients.
Purpose of the Study:
- To quantify cerebrospinal fluid apolipoprotein E (CSF-apoE) concentrations in epilepsy patients.
- To determine if CSF-apoE levels change following seizures.
- To explore correlations between CSF-apoE levels and epilepsy characteristics.
Main Methods:
- Enzyme-linked immunosorbent assay (ELISA) was used to measure CSF-apoE concentrations.
- A cohort of 60 epilepsy patients and 28 healthy controls were analyzed.
- Data were stratified by gender, epilepsy etiology (secondary vs. idiopathic), and seizure type (CPS, SGTC, GTCS, AS).
Main Results:
- Epilepsy patients exhibited significantly lower CSF-apoE levels (5.78+/-2.15 mg/l) compared to controls (13.60+/-12.11 mg/l).
- CSF-apoE levels were lower in males (6.53+/-2.55 mg/l) than females (4.98+/-1.21 mg/l) within the epilepsy group.
- Variations in CSF-apoE were observed across different epilepsy types and seizure classifications.
Conclusions:
- Cerebrospinal fluid apolipoprotein E (CSF-apoE) concentration is reduced in epilepsy patients.
- Post-seizure CSF-apoE levels are influenced by patient gender, etiological factors, and specific seizure types.
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