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Serum resistin in persistent allergic rhinitis: preliminary data in adults
Giorgio Ciprandi1, Mara De Amici, Maria Angela Tosca
1Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino, University of Genoa, Genoa, Italy. gio.cip@libero.it
Resistin levels correlate with symptom severity in adults with persistent allergic rhinitis (PER). Higher resistin serum levels were observed in patients with moderate-to-severe PER symptoms compared to those with mild symptoms.
Area of Science:
- Immunology
- Endocrinology
- Allergy Research
Background:
- Adipokines, including resistin, may play a pro-inflammatory role in allergic rhinitis.
- Previous research on resistin in allergic rhinitis was limited to pediatric populations.
- This study investigated resistin's role in adult persistent allergic rhinitis (PER).
Purpose of the Study:
- To confirm the association between resistin and allergic rhinitis in adults.
- To investigate if resistin serum levels correlate with symptom severity in adult PER patients.
Main Methods:
- Inclusion of 85 adult PER patients categorized by symptom severity (mild vs. moderate-severe).
- Performance of skin prick tests for allergy assessment.
- Measurement of serum resistin levels through blood sampling.
Main Results:
- Adult PER patients with moderate-severe symptoms exhibited significantly higher serum resistin levels compared to those with mild symptoms (p=0.02).
Conclusions:
- Preliminary evidence suggests that serum resistin levels are associated with symptom severity in adult PER patients.
- Resistin may serve as a potential biomarker for allergic rhinitis severity in adults.
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