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Updated: Jun 16, 2026
Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model
Published on: May 6, 2020
[Epidemiology and therapy of osteoarthritis in children]
Y Coulibaly1, A A Diakite, M Keita
1Service de chirurgie pédiatrique, CHU Gabriel, Bamako, Mali. coulibalyyacak@yahoo.fr
Insights
Osteoarthritis in children is infrequent, with sickle cell disease being a major risk factor. Early diagnosis and prompt management are crucial to prevent long-term disability from pediatric osteoarthritis.
Area of Science:
- Pediatric rheumatology
- Infectious disease epidemiology
- Orthopedic surgery
Context:
- Osteoarthritis presents unique challenges in pediatric populations.
- Understanding the epidemiology of pediatric osteoarthritis is essential for resource allocation and treatment protocol development.
- This study focuses on a specific service to determine the frequency and characteristics of pediatric osteoarthritis.
Purpose:
- To determine the incidence of osteoarthritis in children aged 0-15 years within the study service.
- To establish an effective therapeutic protocol for pediatric osteoarthritis.
- To identify common etiologies, affected joints, and causative pathogens in pediatric osteoarthritis.
Summary:
- A retrospective and prospective study identified 41 cases of pediatric osteoarthritis (26 boys, 15 girls) between 2001 and 2004.
- Osteoarthritis accounted for 0.8% of hospitalizations and 1.14% of surgical activities, with a mean patient age of 4.58 years.
- Sickle cell disease was the primary predisposing factor (70.7%), the hip was the most commonly affected joint (48.8%), and Staphylococcus was the most frequent pathogen (48.8%).
Impact:
- Highlights the significant association between sickle cell disease and pediatric osteoarthritis.
- Emphasizes the need for prompt medical evaluation and intervention for children with joint pain to prevent debilitating sequelae.
- Provides data to inform the development of targeted therapeutic strategies and improve patient outcomes in pediatric osteoarthritis.
Objectives:
Establish the frequency of osteoarthritis in our service an establish an adequate therapeutic protocol.
Patients And Methods:
It is about a retro and prospective study realised from January 2001 till January 2004 on all the 0 to 15 years old children treated and followed in the service for osteoarthritis. Ten patients having no complete file or having disappeared during the study were excluded.
Result:
41 cases of osteoarthritis brought together in 26 boys and 15 girls. It occupied 0.8% of the hospitalization and 1.14% of the surgical activities. The average age of our patients was of 4.58 years+/-4.41 with extremes going from 0 to 15 years old. The noted facilitating factor was sickle cell disease (70.7%). The hip was the most affected articulation (48.8%). The staphylococcus was the most met germ (48.8%).
Conclusion:
A meticulous examination of a child presenting an articular pain and its management within a better time are necessary to avoid the frequent invalidating sequel in our country.
