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[Relationship between pulse pressure, visual impairement and severity of diabetic retinopathy in sub-Saharan Africa]
A Nsungu J Nkondi Mbadi1, B Longo-Mbenza, M Mvitu Muaka
1Service d’Ophtalmologie, Hôpital Général de référence de Kinshasa et Université de Kinshasa, RD Congo.
Insights
High pulse pressure (≥60 mmHg) is a significant predictor of diabetic retinopathy, alongside diabetes duration and family history. Early detection and intervention are crucial for preventing vision loss in diabetic patients.
Area of Science:
- Ophthalmology
- Endocrinology
- Public Health
Context:
- Diabetic retinopathy (DR) is a leading cause of vision impairment.
- Understanding DR predictors is vital for effective management, especially in diverse populations.
- A study in Kinshasa, DRC, investigated DR prevalence and risk factors.
Purpose:
- To determine the relationship between pulse pressure, traditional risk factors, vision impairment, and clinical forms of diabetic retinopathy.
- To identify independent predictors of diabetic retinopathy in a Congolese population.
Summary:
- A cross-sectional study in Kinshasa found a 31.6% prevalence of diabetic retinopathy.
- Significant predictors included family history, diabetes duration (≥4 years), and high pulse pressure (≥60 mmHg).
- Vision impairment and subjective acuity decrease were associated with DR, particularly in women and type 2 diabetes patients.
Impact:
- Identifies high pulse pressure as a key modifiable risk factor for diabetic retinopathy.
- Highlights the need for targeted prevention and control programs for DR and its risk factors.
- Provides crucial data for public health strategies in low-resource settings.
Objective:
To determine the relationship between pulse pressure, traditional risk factors, vision impairment and different clinical forms of diabetic retinopathy.
Methods:
A cross-sectional study was conducted between December 1st, 2004 and July 16th, 2005 within the care centers of Kinshasa, DRC. The origin population (n=3010 diabetics) served to estimate the diabetic retinopathy prevalence while a random sample of 301 diabetics participated to this analytic study: age>or=20 years, anthropometry, components of blood pressure, fasting glycaemia, optometry, fundoscopy, stages of diabetic retinopathy.
Results:
The rate of diabetic retinopathy was 31.6% 95 CI: 26.3-36.9 in Kinshasa town. In the random sample, diabetic retinopathy was non proliferative in the majority (90%). Subjective decrease of acuity was associated with diabetic retinopathy in the sample (OR=2.7; 95% CI 1.1-5.4; p<0.05), among women (OR=2.7; 95% CI 1.3-5.7; p<0.05), and in patients with type 2-diabetes (OR=2; 95% CI 1.1-3.4; p<0.05). Objective decrease of acuity was associated with diabetic retinopathy in the study sample (OR=3.6; 95% CI 1.1-12.6; p<0.05). Visual impairment was significantly associated with diabetic retinopathy in women (OR=3.6; 95% CI 1.1-12.6; p<0.05) and proliferative diabetic retinopathy. Pregnancy after diabetes mellitus onset was a significant risk factor of diabetic retinopathy for women (OR=3.2; 95% CI 1.1-13.2; p<0.05). Using logistic regression analysis, family history of diabetic retinopathy (OR=3.2; 95% CI 1.2-8.8; p<0.05), diabetes duration >/=4 years (OR=3.4; 95% CI 1.4-8.5; p<0.01), and pulse pressure>or=60 mmHg (OR=5; 95% CI 2-12.8; p<0.001) were the independent and significant predictors of diabetic retinopathy.
Conclusion:
Urgent programme of prevention and control of diabetic retinopathy and its risk factors is needed.
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