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Fluoridated hydroxyapatites synthesized with organic phosphate ester.

M Okazaki1

  • 1Department of Dental Technology, Osaka University Faculty of Dentistry, Japan.

Biomaterials
|January 1, 1991
PubMed
Summary

Synthesizing fluoridated hydroxyapatites using organic phosphate resulted in higher fluoride content and lower crystallinity compared to inorganic sources. Solubility decreased significantly with increased fluoride, forming calcium fluoride at high concentrations.

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Area of Science:

  • Materials Science
  • Inorganic Chemistry
  • Biomaterials

Background:

  • Hydroxyapatite is a key component of bone and teeth.
  • Fluoridation of hydroxyapatite can enhance its properties, such as acid resistance.
  • The source of phosphate (organic vs. inorganic) may influence the synthesis and properties of fluoridated hydroxyapatites.

Purpose of the Study:

  • To synthesize fluoridated hydroxyapatites using an organic phosphate ester monomer.
  • To compare the fluoride content, crystallinity, and solubility of these materials with those synthesized using inorganic phosphate.
  • To investigate the effect of varying fluoride content on the structural and solubility properties.

Main Methods:

  • Synthesis of fluoridated hydroxyapatites at pH 9.5 and 80°C using an organic phosphate ester.

Related Experiment Videos

  • Characterization of a-axis dimensions and crystallinity.
  • Measurement of apparent solubility at pH 4.0 and 37°C.
  • Detection of calcium fluoride using analytical techniques.

    • Main Results:

    • A-axis dimensions decreased with increasing fluoride content, similar to inorganic phosphate synthesis.
    • Organic phosphate synthesis yielded higher fluoride content in hydroxyapatite for the same feed solution conditions.
    • Crystallinity initially decreased then increased with fluoride content, remaining lower overall than inorganic phosphate derived materials.
    • Apparent solubility decreased monotonically with fluoride content, stabilizing above fluorapatite levels where calcium fluoride was detected.

    Conclusions:

    • Organic phosphate ester is an effective source for synthesizing fluoridated hydroxyapatites with potentially higher fluoride incorporation.
    • The synthesis route impacts crystallinity and fluoride uptake efficiency.
    • Increased fluoridation significantly enhances acid resistance, with implications for dental applications.