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S100B in schizophrenia: an update.

Matthias Rothermundt¹, Jan Niklas Ahn, Silke Jörgens

¹Department of Psychiatry, University of Muenster, D-48149 Muenster, Germany. rothermu@uni-muenster.de

General Physiology and Biophysics

|January 23, 2010

Summary

Immune pathology, particularly astrocyte activation, may play a role in schizophrenia. Elevated S100B levels, a marker of astrocyte activation, correlate with disease severity and poor outcomes in schizophrenia patients.

Area of Science:

Neuroscience
Immunology
Psychiatry

Background:

Emerging evidence suggests immune pathology contributes to schizophrenia pathogenesis.
Viruses and pro-inflammatory cytokines are implicated in the central nervous system (CNS) of patients.
Microglial cells and astrocytes are key immunocompetent cells in the brain, regulating neuronal functions.

Purpose of the Study:

To investigate the role of astrocyte activation, specifically S100B cytokine levels, in schizophrenia.
To explore the association between S100B concentrations and disease characteristics, therapeutic response, and cognitive performance.

Main Methods:

Review of scientific literature on immune markers in schizophrenia.
Analysis of studies measuring S100B concentrations in patients with acute and persistent schizophrenia.

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Correlation analysis between S100B levels and clinical symptoms, cognitive deficits, and treatment outcomes.

Main Results:

Consistent evidence shows increased S100B in acute schizophrenia.
High S100B concentrations are observed in patients with persistent negative symptoms or deficit syndrome.
Elevated S100B is linked to poor therapeutic response and impaired cognitive performance.

Conclusions:

Astrocyte activation, indicated by elevated S100B, is a significant finding in schizophrenia.
Astrocyte activation may be a crucial pathogenic factor in the development and progression of schizophrenia.
S100B serves as a potential biomarker for disease severity and treatment outcomes.