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Related Experiment Video

Updated: Jun 16, 2026

DNA Fingerprinting of Mycobacterium leprae Strains Using Variable Number Tandem Repeat (VNTR) - Fragment Length Analysis (FLA)

DNA Fingerprinting of Mycobacterium leprae Strains Using Variable Number Tandem Repeat (VNTR) - Fragment Length Analysis (FLA)

Published on: July 15, 2011

Drug resistance in leprosy.

Masanori Matsuoka¹

¹Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama, Tokyo, Japan. matsuoka@nih.go.jp

Japanese Journal of Infectious Diseases

|January 23, 2010

Summary

Drug resistance in leprosy is a growing concern. This review covers chemotherapy history, drug resistance mechanisms, and new susceptibility testing methods to combat Mycobacterium leprae resistance.

Area of Science:

Microbiology
Infectious Diseases
Pharmacology

Background:

Leprosy, caused by Mycobacterium leprae, is primarily controlled through multidrug treatment recommended by the World Health Organization (WHO).
The emergence of drug resistance in Mycobacterium leprae strains poses a significant threat to effective leprosy control programs.
Instances of Mycobacterium leprae isolates exhibiting resistance to single and multiple anti-leprosy drugs have been documented.

Purpose of the Study:

To review the historical context of chemotherapy and drug resistance in leprosy.
To explore molecular biological insights into the mechanisms of drug resistance in Mycobacterium leprae.
To introduce novel methodologies for assessing susceptibility to anti-leprosy drugs, moving beyond traditional methods.

Main Methods:

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Published on: March 23, 2014

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Last Updated: Jun 16, 2026

DNA Fingerprinting of Mycobacterium leprae Strains Using Variable Number Tandem Repeat (VNTR) - Fragment Length Analysis (FLA)

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Published on: July 15, 2011

Optimized Protocols for Mycobacterium leprae Strain Management: Frozen Stock Preservation and Maintenance in Athymic Nude Mice

Optimized Protocols for Mycobacterium leprae Strain Management: Frozen Stock Preservation and Maintenance in Athymic Nude Mice

Published on: March 23, 2014

Literature review focusing on chemotherapy history, drug resistance, and molecular mechanisms.
Examination of emerging drug resistance patterns in Mycobacterium leprae.
Introduction and discussion of alternative drug susceptibility testing methods.

Main Results:

Historical overview of leprosy chemotherapy and the evolution of drug resistance.
Elucidation of molecular factors contributing to Mycobacterium leprae drug resistance.
Presentation of updated and alternative methods for drug susceptibility testing.

Conclusions:

Monitoring drug resistance is crucial for preventing the spread of resistant leprosy cases.
Newer susceptibility testing methods offer alternatives to traditional approaches.
Continued vigilance and research are necessary to address the challenge of drug resistance in leprosy management.