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Updated: Jun 16, 2026
Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice
Published on: September 19, 2016
Comparative study of gamma interferon production in mice immunized with outer membrane proteins and whole bacteria of
Seung-Bin Cha1, Nabin Rayamajhi, Mi-Lan Kang
1Department of Infectious Diseases, College of Veterinary Medicine, Seoul National University, Seoul, Korea.
Abstract:
Brucella abortus is the intracellular bacterium that causes bovine brucellosis and a chronic human disease known as undulant fever. Interferon (IFN)-gamma plays critical roles in defending against intracellular bacterial infection. In this experiment, we demonstrated the difference in IFN-gamma production between the splenocytes of mice inoculated with outer membrane proteins (OMPs) of B. abortus and whole live bacteria. Our results showed that the OMP-inoculated group showed more IFN-gamma production than did the bacteria-infected group, suggesting that OMPs are candidates for the induction of immune response.
