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Changes in circulating satiety hormones in obese children: a randomized controlled physical activity-based
Prabhakaran Babu Balagopal1, Samuel S Gidding, Lisa M Buckloh
1Nemours Children's Clinic, Jacksonville, Florida, USA. bbalagop@nemours.org
Obesity (Silver Spring, Md.)
|January 23, 2010
Summary
Childhood obesity alters satiety hormones like leptin and ghrelin. A lifestyle intervention improved these hormone levels, aiding weight management and reducing cardiovascular risk in obese adolescents.
Area of Science:
- Pediatric Endocrinology
- Metabolic Health
- Obesity Research
Background:
- Obesity in children is linked to altered satiety hormones, including leptin, ghrelin, and obestatin.
- These hormonal changes may contribute to cardiometabolic risk factors.
- Early detection of these alterations is crucial for effective intervention.
Purpose of the Study:
- To investigate obesity-related changes in satiety factors (leptin, ghrelin, obestatin) in children.
- To determine the association between satiety factors and cardiometabolic risk.
- To evaluate the impact of a physical activity intervention on satiety factors in obese adolescents.
Main Methods:
- Study included 15 obese and 6 lean adolescents.
- Obese participants underwent a 3-month physical activity lifestyle intervention.
- Measured levels of leptin, ghrelin, obestatin, soluble leptin receptor (sOB-R), inflammation, and insulin resistance.
Main Results:
- Obese children had lower ghrelin, obestatin, and sOB-R, and higher leptin compared to lean controls.
- Intervention increased obestatin and decreased the ghrelin/obestatin ratio, leptin, and increased sOB-R.
- Satiety factors were significantly associated with cardiometabolic risk factors.
Conclusions:
- Obesity in children is associated with early alterations in satiety factor levels.
- Physical activity-based lifestyle interventions can normalize or prevent further increases in these factors.
- These improvements support weight maintenance and cardiovascular risk reduction in obese youth.
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