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Updated: Jun 16, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Published on: February 6, 2020
Short malonyl dehydro peptides as potential scaffolds for peptidomimetics by an efficient Knoevenagel reaction
Stefania Fioravanti1, Simona Gasbarri, Alberto Morreale
1Dipartimento di Chimica, Università degli Studi di Roma La Sapienza, P.le Aldo Moro 5, 00185, Roma, Italy. stefania.fioravanti@uniroma1.it
Abstract:
Non-symmetric disubstituted malonamides rAA-mGly-AA', obtained from Meldrum's acid, were considered as methylene active compounds and a Knoevenagel condensation methodology was developed involving piperidine and activated 4 A molecular sieves as catalysts. The reaction is efficient, broad in scope, and easy to perform and allows access to E/Z mixtures of short malonyl dehydro peptides (MDHPs) rAA-m Delta(2)AA''-AA', partially modified retro peptides characterized by an interesting combination of retro and dehydro modifications in the same structure.
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