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Foreword: eukaryotic DNA replication: is time of the essence?

Marie-Noëlle Prioleau1, Dean A Jackson

  • 1Institut Jacques Monod, UMR7592 CNRS, Université Paris Diderot-Paris 7, BAT. BUFFON-5ème étage-Labo 542, 15,rue Hélène Brion, 75205, Paris cedex 13, France. prioleau.marie-noelle@ijm.univ-paris-diderot.fr

Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology
|January 23, 2010
PubMed
Abstract

No abstract available in PubMed .

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DNA replication involves the separation of the two strands of the double helix, with each strand serving as a template from which the new complementary strand is copied.  After replication, each double-stranded DNA includes one parental or “old” strand and one “new” strand. This is known as semiconservative replication. The resulting DNA molecules have the same sequence and are divided equally into the two daughter cells.
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In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
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