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Published on: May 30, 2020
[Association study between HLA-DRB genes and asthmatic children]
Jing Zhao1, Ming-lian Gu, Juan Bai
1Center for Asthma Research and Education, Capital Institute of Pediatrics, Beijing 100020, China. janezhao0607@yahoo.com
Zhonghua Yi Xue Za Zhi
|January 26, 2010
Summary
The HLA-DRB allele HLA-DR2 (15) is associated with increased susceptibility to childhood asthma in Beijing. Other HLA-DRB alleles like DR4, DR6, DR9, and DR53 showed a protective effect against childhood asthma.
Area of Science:
- Immunogenetics
- Pediatric Allergy
Context:
- Childhood asthma is a significant public health concern.
- Genetic factors, particularly Human Leukocyte Antigen (HLA) genes, play a crucial role in asthma susceptibility.
- Understanding HLA-DRB allele distribution can elucidate genetic predispositions to childhood asthma.
Purpose:
- To investigate the distribution of Human Leukocyte Antigen - DRB (HLA-DRB) alleles in asthmatic children.
- To identify specific HLA-DRB alleles associated with susceptibility or resistance to childhood asthma.
Summary:
- Sequence-specific polymerase chain reaction (SSP-PCR) analyzed HLA-DRB genotypes in 117 asthmatic and 120 healthy children in Beijing.
- The HLA-DR2 (15) allele was significantly more frequent in asthmatic children (12.0%) compared to healthy children (5.4%), indicating susceptibility (OR=2.590).
- Conversely, HLA-DR4, DR6, DR9, and DR53 alleles were less frequent in asthmatic children, suggesting a protective role.
Impact:
- Identifies HLA-DR2 (15) as a susceptibility factor for childhood asthma.
- Suggests HLA-DR4, DR6, DR9, and DR53 may confer resistance to childhood asthma.
- Provides insights into the immunogenetic basis of childhood asthma for potential targeted interventions.
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