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Updated: Jun 16, 2026

Real-time Electrophysiology: Using Closed-loop Protocols to Probe Neuronal Dynamics and Beyond
Published on: June 24, 2015
[The effects of high frequency signal investigated in a neuron model]
Xiaobing Liang1, Xishun Liu, Anzhi Liu
1School of Electronic Science and Engineering, National University of Defense Technology, Changsha 410073, China.
Abstract:
We have investigated the effects of high frequency (HF) signal on firing activity in a biologically realistic system--the noisy Hodgkin-Huxley (HH) neuron model via numerical simulations. The results show that when the HF amplitude to frequency ratio (AFR) increases, the firing rate is diminished and stochastic resonance disappears, even the HH neuron model is processing a stimulus of its most sensitive frequency. When the noise intensity is strong, the vibration resonance can be observed. Moreover, the fluctuation around the resting potential will be replaced by an oscillation of the same high frequency with the increasing AFR. The inhibition of the firing activity is consistent with the results of experiment in vivo that HF current can stop the transmission of action potential in peripheral nerve. This study is of functional significance to the biomedical research on the damages caused by electro-pollution in vivo and signal processing.
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