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Mucoadhesion: a review of characterization techniques.
Maya Davidovich-Pinhas1, Havazelet Bianco-Peled
1Department of Chemical Engineering, Technion, Haifa 32000, Israel.
Expert Opinion on Drug Delivery
|January 26, 2010
Summary
Mucoadhesive drug delivery systems enhance drug absorption and bioavailability. This review categorizes and compares experimental mucoadhesion characterization methods to aid researchers in selecting appropriate techniques.
Area of Science:
- Pharmaceutical Sciences
- Biomaterials Science
- Drug Delivery Systems
Background:
- Mucoadhesive drug delivery vehicles offer extended residence time, rapid systemic uptake, and enhanced bioavailability.
- Mucoadhesion is critical for drug delivery systems targeting mucus-covered tissues like the mouth and respiratory tract.
Purpose of the Study:
- To review and categorize experimental methods for mucoadhesion characterization.
- To provide a comparison of different mucoadhesion testing techniques.
Main Methods:
- Categorization of techniques into direct (force/time of detachment) and indirect (mucin-glycoprotein interactions) methods.
- Analysis of numerous experimental methods proposed for mucoadhesion characterization.
Main Results:
- A comprehensive description of available mucoadhesion characterization techniques is provided.
- Facilitates the selection of appropriate characterization methods for specific studies.
- Comparison of results across different laboratories is presented where possible.
Conclusions:
- A universal test method for comparing mucoadhesion data across research groups remains a challenge.
- Ranking new mucoadhesion candidates with a standardized method has not yet been achieved.
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01:14Adhesion
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01:14Cell Adhesion in Plants
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01:28Types of Membrane Protrusions
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