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Related Concept Videos

Positive Regulator Molecules01:45

Positive Regulator Molecules

To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.
Positive Regulator Molecules02:39

Positive Regulator Molecules

Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
Polytene Chromosomes02:04

Polytene Chromosomes

Polytene chromosomes are giant interphase chromosomes with several DNA strands placed side by side. They were discovered in the year 1881 by Balbiani in salivary glands, intestine, muscles, malpighian tubules, and hypoderm of larvae Chironomus plumosus. Hence, these are also called "Salivary gland chromosomes." These are found in insects of the order Diptera and Collembola; in certain organs of mammals; and synergids, antipodes of flowering plants. Polytene chromosomes are also regularly...
Feedback Regulation of Calcium Concentration01:27

Feedback Regulation of Calcium Concentration

Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
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Amino Acid Biosynthetic Pathways01:29

Amino Acid Biosynthetic Pathways

Amino acid biosynthesis is essential for cell growth, protein synthesis, and metabolic regulation. Cells generate essential and non-essential amino acids from metabolic intermediates to sustain vital biological functions. These intermediates originate from key metabolic pathways: glycolysis, the tricarboxylic acid (TCA) cycle, and the pentose phosphate pathway. Important precursors include α-ketoglutarate, pyruvate, oxaloacetate, phosphoenolpyruvate, and erythrose-4-phosphate, which provide...
Nuclear Protein Sorting01:34

Nuclear Protein Sorting

Nuclear protein sorting is the selective trafficking of histones, polymerases, gene regulatory proteins into the nucleus and exporting RNAs and ribosomes to the cytosol. It is a tightly controlled process that regulates gene expression within a cell.
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Related Experiment Video

Updated: Jun 16, 2026

Facile Protocol for the Synthesis of Self-assembling Polyamine-based Peptide Amphiphiles (PPAs) and Related Biomaterials
08:55

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Published on: June 25, 2018

Cells and polyamines do it cyclically.

Kersti Alm1, Stina Oredsson

  • 1Department of Cell and Organism Biology, Lund University, Lund, Sweden. Stina.Oredsson@cob.lu.se

Essays in Biochemistry
|January 26, 2010
PubMed
Summary

Polyamines are crucial for cell cycle progression, particularly DNA replication. Inhibiting polyamine increases in G(0)/G(1) phase cells prolongs S-phase, highlighting their role in cell division.

Area of Science:

  • Cell Biology
  • Molecular Biology

Background:

  • Cell cycle progression involves distinct phases: G(1), S, G(2), and M.
  • The G(0) phase represents a non-proliferating state.
  • DNA duplication during S-phase is a critical cell cycle event.

Purpose of the Study:

  • To investigate the role of polyamines in cell cycle progression.
  • To understand how polyamine levels influence DNA replication.

Main Methods:

  • Studied polyamine biosynthesis and regulation during the cell cycle.
  • Examined the effect of inhibiting polyamine increases on cell cycle phases.

Main Results:

  • Polyamine biosynthesis peaks during G(1)/S transition, S-phase, and G(2)-phase.

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  • Antizyme activity is inversely correlated with polyamine biosynthesis.
  • Inhibiting polyamine increases in G(0)/G(1) cells prolonged S-phase.

    • Conclusions:

    • Polyamines play a vital role in enabling optimal DNA replication rates.
    • Cell-cycle-related increases in polyamine pools are essential for efficient cell division.