Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
Alzheimer Disease ll: Pathophysiology01:23

Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...
Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Position is important: retrograde air embolism after central venous catheter removal.

Neurologia·2022
Same author

Ischaemic stroke as a complication of cardiac catheterisation. Clinical and radiological characteristics, progression, and therapeutic implications.

Neurologia·2022
Same author

Clinico-radiological related to early brain death factors.

Medicina intensiva·2021
Same author

Rehabilitation in adult post-COVID-19 patients in post-acute care with Therapeutic Exercise.

The Journal of frailty & aging·2021
Same author

[Analysis of SARS-CoV-2 in the air of an ICU dedicated to covid-19 patients].

Medicina intensiva·2021
Same author

Safety and outcomes of routine endovascular thrombectomy in large artery occlusion recorded in the SITS Register: An observational study.

Journal of internal medicine·2021

Related Experiment Video

Updated: Jun 16, 2026

Ultrasonographic Evaluation of Salivary Glands for Sjogren's Syndrome: Diagnostic and Monitoring Insights
07:25

Ultrasonographic Evaluation of Salivary Glands for Sjogren's Syndrome: Diagnostic and Monitoring Insights

Published on: October 13, 2023

Is there progressive cognitive dysfunction in Sjögren Syndrome? A preliminary study.

S Martínez1, C Cáceres, M Mataró

  • 1Neurology Department, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.

Acta Neurologica Scandinavica
|January 26, 2010
PubMed
Summary

Cognitive dysfunction in primary Sjögren Syndrome (SS) and migraine patients did not significantly worsen over 8 years. Both groups showed some deficits, with SS patients reporting higher depression and fatigue.

More Related Videos

Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients
05:26

Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients

Published on: March 1, 2024

Related Experiment Videos

Last Updated: Jun 16, 2026

Ultrasonographic Evaluation of Salivary Glands for Sjogren's Syndrome: Diagnostic and Monitoring Insights
07:25

Ultrasonographic Evaluation of Salivary Glands for Sjogren's Syndrome: Diagnostic and Monitoring Insights

Published on: October 13, 2023

Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients
05:26

Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients

Published on: March 1, 2024

Area of Science:

  • Neuroscience
  • Rheumatology
  • Psychology

Background:

  • Primary Sjögren Syndrome (SS) is an autoimmune disease potentially affecting the central nervous system.
  • Cognitive dysfunction is a reported symptom in SS, but its progression is not well understood.
  • Comparing SS with migraine, a condition with overlapping symptoms, can clarify SS-specific cognitive changes.

Purpose of the Study:

  • To determine the progression of cognitive dysfunction in primary Sjögren Syndrome (SS) over an 8-year period.
  • To compare cognitive performance in SS patients with those who have migraine and healthy controls.
  • To investigate changes in mood and fatigue alongside cognitive function.

Main Methods:

  • Twelve SS patients, ten migraine patients, and ten healthy controls underwent neuropsychological, mood, and fatigue testing at baseline and after 8 years.
  • Neuropsychological tests included the Continuous Performance Test (CPT), Wisconsin Card Sorting Test (WCST), Benton's Judgment of Line Orientation Test (JOLO), and others measuring reaction time, verbal fluency, and memory.
  • Mood and fatigue were assessed using standardized scales.

Main Results:

  • At 8-year follow-up, SS patients performed worse than migraine patients on the CPT.
  • Both SS and migraine groups showed impairments in simple reaction time, Trail Making Test B, Stroop, and JOLO compared to baseline.
  • Despite some impairments, both groups showed improved verbal/visual memory, WCST, and CPT reaction time; no significant cognitive decline over time was observed.
  • SS patients reported higher depression and fatigue levels than migraine patients and controls, with no significant changes over time.

Conclusions:

  • Preliminary findings suggest fronto-subcortical cognitive deficits in both SS and migraine patients.
  • Cognitive function did not significantly decline over the 8-year study period in either clinical group.
  • SS is associated with higher levels of depression and fatigue, independent of cognitive changes over time.