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Updated: Jun 16, 2026
Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension
Published on: January 20, 2023
Early right ventricular systolic dysfunction in patients with systemic sclerosis without pulmonary hypertension: a
Sebastian Schattke1, Fabian Knebel, Andrea Grohmann
1Universitätsmedizin Berlin, Medical Clinic for Cardiology and Angiology, Charité Campus Mitte, Charitéplatz 1, 10117 Berlin, Germany. sebastian.schattke@charite.de
Background:
Isovolumetric acceleration (IVA) is a novel tissue Doppler parameter for the assessment of systolic function. The aim of this study was to evaluate IVA as an early parameter for the detection of right ventricular (RV) systolic dysfunction in patients with systemic sclerosis (SSc) without pulmonary hypertension.
Methods:
22 patients and 22 gender- and age-matched healthy subjects underwent standard echocardiography with tissue Doppler imaging (TDI) and speckle tracking strain to assess RV function.
Results:
Tricuspid annular plane systolic excursion (TAPSE) (23.2 +/- 4.1 mm vs. 26.5 +/- 2.9 mm, p < 0.006), peak myocardial systolic velocity (Sm) (11.6 +/- 2.3 cm/s vs. 13.9 +/- 2.7 cm/s, p = 0.005), isovolumetric contraction velocity (IVV) (10.3 +/- 3 cm/s vs. 14.8 +/- 3 cm/s, p < 0.001) and IVA (2.3 +/- 0.4 m/s2 vs. 4.1 +/- 0.8 m/s2, p < 0.001) were significant lower in the patient group. IVA was the best parameter to predict early systolic dysfunction with an area under the curve of 0.988.
Conclusion:
IVA is a useful tool with high-predictive power to detect early right ventricular systolic impairment in patients with SSc and without pulmonary hypertension.
