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Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
10:49

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus

Published on: January 28, 2019

Incidence of hospitalization due to community-acquired rotavirus infection: a 12-year study (1996-2008)

G Cilla1, M Gomariz, M Montes

  • 1Servicio de Microbiología, Hospital Donostia, San Sebastián, Spain. carlosgustavo.cillaeguiluz@osakidetza.net

Epidemiology and Infection
|January 26, 2010
PubMed

Insights

Hospitalizations for rotavirus acute gastroenteritis (AGE) significantly decreased in young children after 2002. This decline in rotavirus AGE hospitalizations coincided with increased oral rehydration solution use.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Vaccinology

Background:

  • Acute gastroenteritis (AGE) hospitalizations are key indicators for evaluating rotavirus vaccine effectiveness in high-income nations.
  • Rotavirus is a leading cause of severe gastroenteritis in infants and young children worldwide.

Purpose of the Study:

  • To assess the impact of rotavirus vaccination on hospitalization rates for acute gastroenteritis in children under 5 years old.
  • To determine the predominant rotavirus genotypes circulating in hospitalized children.

Main Methods:

  • Retrospective analysis of hospital discharge data and microbiology records from Hospital Donostia.
  • Investigation of rotavirus antigen in fecal samples from 1114 children hospitalized for AGE.
  • Genotyping of rotavirus strains.

Main Results:

  • Rotavirus was detected in approximately 40% of hospitalized children with AGE, with G1[P8] as the most common genotype.
  • The annual incidence of rotavirus AGE hospitalizations decreased significantly from 1996-1999 to 2002-2005 in children under 5 and under 2 years old (P<0.001).
  • The observed decrease in rotavirus AGE hospitalizations correlated with increased consumption of oral rehydration solutions.

Conclusions:

  • Rotavirus vaccination has likely contributed to a substantial reduction in rotavirus-associated AGE hospitalizations in young children.
  • Continued surveillance of rotavirus epidemiology and vaccination impact is crucial.
  • Increased use of oral rehydration solutions may play a complementary role in managing AGE.

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