The uncertain status of cutaneous pseudolymphoma

Cutaneous pseudolymphomas (CPLs) include a wide range of clinicopathological presentations sharing in common the presence of clinical and histopathological features mimicking those of primary cutaneous lymphomas. Although immunophenotypical studies and molecular analysis of clonality have been shown to be reliable tools, providing significant help in the differential diagnosis between primary cutaneous lymphoid malignancy and pseudolymphoma involving the skin, the identification of an etiological agent and prolonged follow-up remain the key steps to ascertain the benign, reactive nature of a skin lymphocytic infiltrate.