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Lobomycosis. Literature review and future perspectives
M Ramos-E-Silva1, F Aguiar-Santos-Vilela, A Cardoso-de-Brito
1Sector of Dermatology and Post-Graduation Course in Dermatology, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. ramos.e.silva@dermato.med.br
Actas Dermo-Sifiliograficas
|January 26, 2010
Summary
Lobomycosis is a chronic fungal skin infection caused by Lacazia loboi, prevalent in tropical regions. Early diagnosis and treatment, including surgery and antifungals, are crucial for managing this keloid-like skin disease.
Area of Science:
- Mycology
- Dermatology
- Infectious Diseases
Background:
- Lobomycosis is a chronic fungal infection caused by Lacazia loboi, endemic to tropical and subtropical regions.
- The disease presents with keloid-like skin lesions, primarily affecting exposed areas, with no systemic involvement.
- Lacazia loboi's taxonomic position remains controversial, and the fungus has not yet been successfully cultured in vitro.
Purpose of the Study:
- To review the current understanding of lobomycosis, including its clinical presentation, diagnosis, and treatment.
- To highlight the importance of recognizing lobomycosis globally due to its potential spread beyond endemic areas.
- To emphasize the need for further research, particularly in molecular biology and genetic engineering, to improve diagnosis and treatment.
Main Methods:
- Review of existing literature on lobomycosis.
- Clinical and histopathological diagnostic methods.
- Surgical and pharmacological treatment approaches.
Main Results:
- Lobomycosis is characterized by chronic, keloid-like skin lesions, predominantly in exposed areas.
- Surgical excision is the primary treatment for isolated lesions, but recurrences are common.
- Positive therapeutic responses have been observed with clofazimine, itraconazole, and 5-fluorocytosine.
Conclusions:
- Lobomycosis requires wider recognition among dermatologists worldwide.
- Advancements in molecular biology and genetic engineering are essential for future progress in culturing the fungus, understanding pathogenesis, and developing novel diagnostic and therapeutic strategies.
- Further research is crucial for improved management and prevention of lobomycosis.
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