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Lubrication in tablet formulations.

Jennifer Wang1, Hong Wen, Divyakant Desai

  • 1Bristol-Myers Squibb Company, New Brunswick, NJ, United States. jennifer.wang@bms.com <jennifer.wang@bms.com>

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V
|January 26, 2010
PubMed
Summary
This summary is machine-generated.

This review covers tablet compression lubrication, focusing on lubricant properties like magnesium stearate and manufacturing impacts. It details characterization methods and Quality-by-Design for optimal tablet formulation.

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Lubrication is crucial in tablet compression to prevent sticking and ensure smooth tablet ejection.
  • Common lubricants, like magnesium stearate, have specific properties influencing tablet characteristics.
  • Manufacturing processes can significantly impact lubrication effectiveness and tablet quality.

Purpose of the Study:

  • To provide a comprehensive review of lubrication in tablet compression.
  • To summarize lubricant properties and their effects on tablet physical and chemical attributes.
  • To discuss process factors, characterization methodologies, and Quality-by-Design for tablet lubrication.

Main Methods:

  • Literature review of theoretical and practical aspects of tablet lubrication.
  • Summary of properties for common tablet lubricants (e.g., magnesium stearate).
  • Discussion of manufacturing process variables affecting lubrication.
  • Review of methodologies for characterizing the lubrication process using Process Analytical Technology (PAT).

Main Results:

  • Lubricants, while essential, can alter tablet physical and chemical properties.
  • Understanding lubricant material properties is key to successful tablet manufacturing.
  • Various PAT tools can effectively characterize and monitor the lubrication process during compression.

Conclusions:

  • Effective lubrication management is critical for successful tablet formulation and manufacturing.
  • Quality-by-Design principles should be applied to optimize tablet lubrication and ensure consistent product quality.
  • Further research into lubricant-excipient interactions and advanced characterization techniques is warranted.