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Published on: July 12, 2024
Periodontal and coronary heart disease in patients undergoing coronary angiography
Robert Berent1, Johann Auer, Peter Schmid
1Center for Cardiovascular Rehabilitation, Bad Schallerbach, Austria.
Insights
Periodontal disease (PD) is linked to coronary heart disease (CHD). Patients with PD had a higher likelihood of having CHD, suggesting PD may be a modifiable risk factor.
Area of Science:
- Cardiology
- Periodontology
- Epidemiology
Background:
- Periodontal inflammation is associated with atherosclerosis and coronary heart disease (CHD).
- Few studies have explored the link between periodontal disease (PD) and coronary atherosclerosis assessed via coronary angiography (CA).
Purpose of the Study:
- To investigate the association between coronary heart disease (CHD) and periodontal disease (PD).
Main Methods:
- A prospective epidemiological study involving 466 patients undergoing coronary angiography (CA).
- Patients received comprehensive physical, laboratory, cardiac, and dental examinations, including dental X-rays.
- Periodontal disease (PD) and coronary angiograms were evaluated independently by a dentist and two cardiologists, respectively.
Main Results:
- Coronary heart disease (CHD) was identified in 74.9% of patients.
- Periodontal disease (PD) was more prevalent in patients with CHD (55.6%) compared to those without (41.9%).
- After adjusting for risk factors, PD remained significantly associated with CHD (odds ratio = 1.9).
Conclusions:
- Periodontal disease (PD) is associated with a higher likelihood of angiographically determined coronary heart disease (CHD).
- CHD and PD may coexist within specific population groups.
- PD is a potentially modifiable, preventable, and treatable risk factor for CHD.
Abstract:
Periodontal inflammation has been implicated in atherosclerosis and coronary heart disease (CHD). Coronary angiography (CA) is used in the assessment of CHD; only a few studies have evaluated periodontal disease (PD) and angiographic measures of coronary atherosclerosis. The aim of this study was to investigate the association between CHD and PD. In this prospective epidemiologic study, 466 patients underwent CA and were assessed for PD. All patients underwent physical, laboratory, cardiac, and dental examination including dental x-rays. Periodontal disease and coronary angiograms were evaluated blindly by a dentist and 2 cardiologists, respectively. A coronary stenosis greater than 50% was ruled as CHD. Periodontal disease was defined and measured with the Community Periodontal Index of Treatment Needs (CPITN); and if at least 2 sextants (segments dividing mandible and maxilla into 6) were recorded as having CPITN of at least 3 (signifying that sextant had periodontal pocket depth ≥ 3.5 mm), the patient was coded as having PD. Three-hundred forty-nine patients (74.9%) had CHD assessed by CA The CHD patients had PD in 55.6% vs 41.9% in the non-CHD patients (P < .01). The CPITN scores were significantly higher in patients with vs without CHD, 2.43 vs 2.16, respectively (P = .023). After adjusting for age, sex, and risk factors for atherosclerosis with additional inclusion of C-reactive protein and erythrocyte sedimentation rate, PD remained significantly related to CHD (odds ratio = 1.9; 95% confidence interval, 1.2-3.1). Other predictors for CHD were male sex, age, high-density lipoprotein cholesterol, and diabetes. Our results demonstrate an increased odds ratio for angiographically determined CHD in patients with PD and that CHD and PD may cluster in particular groups of a population. Our data indicate that PD represents a potentially modifiable risk factor that is both preventable and treatable with predictable treatments that pose negligible risk.
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