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Published on: September 22, 2011
Mechanism of the vasodilator effect of Euxanthone in rat small mesenteric arteries
D V Câmara1, V S Lemos, M H Santos
1Departamento de Farmacologia, Instituto de Ciências Biológicas - Universidade Federal de Minas Gerais. Belo Horizonte - MG, Brazil.
Abstract:
In the present work we investigated the mechanism involved in the vasodilator effect induced by euxanthone in rat small mesenteric arteries. We observed that euxanthone induced concentration-dependent vasodilatation in arteries by a mechanism independent on the release of endothelial factors, such as nitric oxide (NO) and cyclooxygenase-derived factors. In addition our results also suggest that euxanthone induced its vasodilator effect through inhibition of calcium-sensitive mechanisms activated by protein kinase C, rather than by inhibition of contractions dependent on the release of the intracellular calcium stores or by inhibition of voltage-operated calcium channels.
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