Related Experiment Video
Updated: Jun 16, 2026

Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase
Published on: April 29, 2010
Recruitment to stalled replication forks of the PriA DNA helicase and replisome-loading activities is essential for
Carolina B Gabbai1, Kenneth J Marians
1Molecular Biology Program, Weill-Cornell Graduate School of Medical Sciences, New York, NY, USA. cbg2002@med.cornell.edu
Abstract:
PriA, a 3'-->5' superfamily 2 DNA helicase, acts to remodel stalled replication forks and as a specificity factor for origin-independent assembly of a new replisome at the stalled fork. The ability of PriA to initiate replication at stalled forked structures ensures complete genome replication and helps to protect the cell from illegitimate recombination events. This review focuses on the activities of PriA and its role in replication fork assembly and maintaining genomic integrity.
Related Concept Videos
Restarting Stalled Replication Forks
Restarting Stalled Replication Forks
The DNA Replication Fork
The DNA Replication Fork
DNA Damage can Stall the Cell Cycle
DNA Damage Can Stall the Cell Cycle

