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Related Experiment Video

Updated: Jun 16, 2026

Intravital Microscopy of Tumor-associated Vasculature Using Advanced Dorsal Skinfold Window Chambers on Transgenic Fluorescent Mice

Intravital Microscopy of Tumor-associated Vasculature Using Advanced Dorsal Skinfold Window Chambers on Transgenic Fluorescent Mice

Published on: January 19, 2018

Troubleshooting methods: Using intravital microscopy in drug research.

Ellen L Hughes¹, Felicity N E Gavins

¹Centre of Neuroscience, Imperial College London, United Kingdom.

Journal of Pharmacological and Toxicological Methods

|January 26, 2010

Summary

Intravital microscopy allows real-time observation of cellular interactions, proving valuable in drug research. This review details its applications, suitable vascular beds like the cremaster muscle, and data collection methods.

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Area of Science:

Pharmacology
Cell Biology
Microscopy

Background:

Intravital microscopy is a recognized technique for observing cellular interactions in real time.
Its application in drug research offers significant potential for understanding biological processes.

Purpose of the Study:

To review the potential uses and pitfalls of intravital microscopy in drug research.
To provide guidance on selecting appropriate vascular beds and measurement types.

Main Methods:

Review of existing literature and applications of intravital microscopy.
Emphasis on specific vascular beds: cremaster muscle, mesentery, and brain.
Discussion of various measurement types applicable to drug research.

Main Results:

Intravital microscopy is a versatile technique with broad applications in drug discovery.
Selection of the vascular bed (e.g., cremaster muscle, mesentery, brain) is crucial for experimental design.
Technical advice and examples are provided to facilitate its use.

Conclusions:

Intravital microscopy is a powerful tool for drug research, offering real-time insights into cellular dynamics.
Careful consideration of experimental parameters, including vascular bed choice and measurement techniques, is essential for successful application.