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Related Experiment Video

Updated: Jun 16, 2026

Dual-mode Imaging of Cutaneous Tissue Oxygenation and Vascular Function

Dual-mode Imaging of Cutaneous Tissue Oxygenation and Vascular Function

Published on: December 8, 2010

Topical dissolved oxygen penetrates skin: model and method.

David F Roe¹, Bruce L Gibbins, Daniel A Ladizinsky

¹Department of Research and Development, AcryMed, Inc., Beaverton, Oregon 97008, USA. droe@acrymed.com

The Journal of Surgical Research

|January 26, 2010

Summary

Topical oxygen, including dissolved oxygen (TDO), can penetrate human skin. This study demonstrates that TDO effectively delivers oxygen transcutaneously, surpassing topical gaseous oxygen (TGO) delivery.

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Fabrication and Operation of an Oxygen Insert for Adherent Cellular Cultures

Fabrication and Operation of an Oxygen Insert for Adherent Cellular Cultures

Published on: January 6, 2010

Area of Science:

Dermatology
Biophysics
Biomedical Engineering

Background:

Traditionally, skin oxygenation was attributed solely to internal circulation.
Emerging research suggests external oxygen absorption significantly contributes to skin oxygen supply.
A novel method was developed to quantify transcutaneous oxygen penetration.

Purpose of the Study:

To measure the depth and extent of oxygen penetration into human skin from topical sources.
To compare the efficacy of topical dissolved oxygen (TDO) versus topical gaseous oxygen (TGO) delivery.
To investigate the influence of skin layers (epidermis and dermis) on oxygen penetration.

Main Methods:

Utilized an apparatus with human skin samples separating a topical oxygen source from a fluid-filled chamber.
Employed viable human skin samples of varying thicknesses, with and without epidermis.
Assessed oxygen penetration from both TDO and TGO devices by monitoring dissolved oxygen changes.

Main Results:

The developed model successfully demonstrated transcutaneous oxygen penetration.
Topically applied dissolved oxygen was found to penetrate human skin to depths exceeding 700 micrometers.
Oxygen penetration was more efficient through the dermis compared to the epidermis.

Conclusions:

Topical oxygen application is a viable method for skin oxygenation.
Topical dissolved oxygen (TDO) devices are more effective at delivering oxygen transcutaneously than topical gaseous oxygen (TGO) devices.
Understanding oxygen penetration dynamics is crucial for developing advanced topical oxygen therapies.