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Updated: Jun 16, 2026

Venous Thrombosis Assay in a Mouse Model of Cancer
Published on: January 5, 2024
Venous thromboembolism and prognosis in cancer
1James P. Wilmot Cancer Center, and the Department of Medicine, University of Rochester, Rochester, NY 14642, USA. alok_khorana@URMC.rochester.edu
Abstract:
Venous thromboembolism (VTE) is a frequent complication of malignancy, and its incidence has increased markedly in recent years. VTE itself can directly lead to patient mortality, and is the second leading cause of death in patients with cancer. Furthermore, emerging data suggest that activation of coagulation in malignancy is integrally linked with tumor biology, particularly with angiogenesis. The development of the clinical hypercoagulable state is also linked with adverse prognosis in patients with cancer, including patients receiving systemic chemotherapy. This review focuses on the clinical evidence documenting a link between VTE and adverse short-term and long-term prognosis in patients with cancer.
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