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Related Experiment Videos

Creatine kinase MB elevation in paralytic shellfish poisoning.

H S Cheng1, S O Chua, J S Hung

  • 1Department of Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan, Republic of China.

Chest
|April 1, 1991
PubMed
Summary

An outbreak of paralytic shellfish poisoning caused by gonyautoxins in purple clams sickened 116 people. Elevated creatine kinase MB levels were observed in patients, a previously unreported finding in paralytic shellfish poisoning.

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Area of Science:

  • Toxicology
  • Neuroscience
  • Public Health

Background:

  • Paralytic Shellfish Poisoning (PSP) is a serious illness caused by consuming shellfish contaminated with marine biotoxins.
  • An outbreak of PSP occurred in southern Taiwan linked to the consumption of purple clams.

Purpose of the Study:

  • To report on the clinical features and laboratory findings of patients with paralytic shellfish poisoning during a significant outbreak.
  • To highlight the previously unreported observation of elevated creatine kinase MB levels in affected individuals.

Main Methods:

  • Clinical case series of five patients admitted to the hospital during the PSP outbreak.
  • Analysis of patient symptoms, treatment outcomes, and laboratory markers, including serum creatine kinase and creatine kinase MB levels.

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Main Results:

  • The outbreak affected 116 individuals, with two fatalities, following consumption of purple clams containing gonyautoxins.
  • Five hospitalized patients with PSP all recovered with supportive care.
  • Elevated serum creatine kinase was noted in three patients, but did not correlate with poisoning severity.
  • Creatine kinase MB levels were elevated in all four patients tested, representing a novel finding in PSP.

Conclusions:

  • Gonyautoxins from purple clams caused a severe PSP outbreak in Taiwan.
  • Supportive treatment is effective for PSP.
  • Elevated creatine kinase MB may be a potential biomarker in paralytic shellfish poisoning, warranting further investigation.