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Reversible brain death. A manifestation of amitriptyline overdose
1Division of Pulmonary and Critical Care Medicine, University of Texas Health Science Center, Houston.
Chest
|April 1, 1991
Abstract:
Tricyclic antidepressants are known to cause central nervous system depression. However, a generalized depression of brainstem functions is rarely reported. We report a patient in deep coma with complete absence of brain-stem reflexes after she had taken a large quantity of amitriptyline. With continuous supportive treatment, she eventually regained all neurologic function and made a full recovery.