Electrocardiographic and electrophysiologic features of ventricular arrhythmias originating from the right/left
Rupa Bala1, Fermin C Garcia, Mathew D Hutchinson
1Electrophysiology Section, Cardiovascular Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Insights
Ventricular arrhythmias from the right coronary cusp-left coronary cusp (RCC-LCC) commissure are common. These arrhythmias exhibit a distinct QS morphology in lead V(1) and often show late potentials at the ablation site.
Area of Science:
- Cardiology
- Electrophysiology
- Cardiac Anatomy
Background:
- Ventricular arrhythmias frequently originate from the aortic sinus of Valsalva.
- The specific characteristics of arrhythmias from the right coronary cusp-left coronary cusp (RCC-LCC) commissure require further elucidation.
Purpose of the Study:
- To identify the distinct anatomical and electrocardiographic characteristics of ventricular arrhythmias originating from the RCC-LCC commissure.
- To compare these characteristics with arrhythmias from other aortic cusp regions.
Main Methods:
- Utilized intracardiac echocardiography and electroanatomic mapping in 37 patients with aortic cusp ventricular arrhythmias.
- Defined coronary cusp anatomy and catheter positions.
- Compared arrhythmias from the RCC-LCC commissure with those from other aortic cusp sites.
Main Results:
- 51% of ventricular arrhythmias originated from the RCC-LCC commissure.
- A QS morphology in lead V(1) with notching was significantly more common in RCC-LCC arrhythmias (15/19) compared to other sites (2/18).
- Late potentials in sinus rhythm at the earliest activation site were observed in 13/19 RCC-LCC arrhythmias versus 1/18 from other sites. Successful ablation was above the aortic valve plane in 79% of RCC-LCC cases.
Conclusions:
- Ventricular arrhythmias from the RCC-LCC aortic cusp are prevalent.
- These arrhythmias are characterized by QS morphology in lead V(1) with precordial transition at V(3).
- Successful ablation sites typically exhibit late potentials in sinus rhythm.
Background:
Ventricular arrhythmias are known to originate from the aortic sinus of Valsalva.
Objective:
The purpose of this study was to identify the characteristics associated with ventricular arrhythmias originating from the right coronary cusp-left coronary cusp (RCC-LCC) commissure.
Methods:
Thirty-seven consecutive patients with ventricular arrhythmias originating from the aortic cusp region were studied. Intracardiac echocardiography and electroanatomic mapping were used to define coronary cusp anatomy and catheter position. Ventricular arrhythmias from the RCC-LCC commissure were compared with ventricular arrhythmias originating from other sites in the aortic cusp region.
Results:
Nineteen (51%) ventricular arrhythmias had an anatomic origin at the RCC-LCC commissure. Eighteen ventricular arrhythmias originated from other aortic cusp sites (4 right cusp, 7 left cusp, 3 left ventricular endocardium, 4 left ventricular epicardium anterior to aortic valve). A QS morphology in lead V(1) with notching on the downward deflection was present in 15 of 19 ventricular arrhythmias originating from the RCC-LCC commissure compared to 2 of 18 ventricular arrhythmias from other aortic cusp sites (P <.01). At the site of earliest activation, 13 of 19 patients with RCC-LCC ventricular arrhythmias had late potentials in sinus rhythm compared to 1 of 18 ventricular arrhythmias from other aortic cusp sites (P <.01). The site of successful ablation was confirmed to be above the aortic valve plane in 15 (79%) of 19 patients with RCC-LCC ventricular arrhythmias.
Conclusion:
RCC-LCC aortic cusp ventricular arrhythmias are common and have a QS morphology in lead V(1) with notching on the downward deflection with precordial transition at lead V(3). In the majority of cases, the site of successful ablation has late potentials in sinus rhythm.
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