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Updated: Jun 16, 2026

Application of Dixon's Up-and-Down Design to Estimate the Minimum Alveolar Concentration of Sevoflurane in Rats with Refined Movement Classification
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Application of Dixon's Up-and-Down Design to Estimate the Minimum Alveolar Concentration of Sevoflurane in Rats with Refined Movement Classification

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Brainstem regions affecting minimum alveolar concentration and movement pattern during isoflurane anesthesia.

Steven L Jinks1, Milo Bravo, Omar Satter

  • 1Department of Anesthesiology and Pain Medicine, University of California-Davis School of Medicine, Davis, CA 95616, USA. sljinks@ucdavis.edu

Anesthesiology
|January 26, 2010
PubMed
Summary

Brainstem regions, particularly the mesencephalic locomotor region, significantly influence anesthetic requirements and movement responses to isoflurane. This region facilitates spinal locomotor circuits, impacting anesthetic immobility effects.

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