Geographical variation of mortality from cardiovascular diseases. The Project 'Myocardial Infarction in mid-Sweden'
Related Experiment Video
Updated: Jul 20, 2026

Isolation of Cardiomyocyte Nuclei from Post-mortem Tissue
Published on: July 10, 2012
C Nerbrand1, K Svärdsudd, L G Hörte
1Uppsala University, Department of Family Medicine, Sweden.
Insights
Geographical variations in mortality rates were observed in mid-Sweden. Cardiovascular disease mortality was higher in western communities, with significant excess mortality from ischaemic heart disease and stroke.
Area of Science:
- Public Health
- Epidemiology
- Cardiovascular Research
Background:
- Geographical variations in mortality rates can indicate underlying environmental or lifestyle factors.
- Understanding regional disparities in cardiovascular disease (CVD) mortality is crucial for targeted public health interventions.
Purpose of the Study:
- To investigate geographical variations in mortality rates across mid-Sweden.
- To analyze differences in mortality from all causes, cardiovascular diseases, and non-cardiovascular diseases by region.
Main Methods:
- Utilized mortality data from 76 communities in mid-Sweden for men and women aged 45-74.
- Data included all-cause, cardiovascular, cerebrovascular, ischaemic heart disease (IHD), and non-cardiovascular mortality.
- Age standardization was applied to account for differences in population age structures.
Main Results:
- Mortality from all causes and cardiovascular diseases was significantly higher in western communities compared to eastern ones.
- No systematic differences in non-cardiovascular mortality were found between regions.
- Excess mortality rates for IHD and stroke were notably higher in specific western counties for both men and women.
Conclusions:
- Significant geographical disparities in cardiovascular and overall mortality exist within mid-Sweden.
- The observed variations are not attributable to age distribution, registration differences, or case fatality rates.
- Further research is needed to identify the unknown causes of these regional mortality differences.
Abstract:
In this study, the geographical variation of the mortality rate in mid-Sweden was studied. Data on mortality from all causes and mortality from cardiovascular diseases, cerebrovascular diseases, ischaemic heart disease (IHD) and non-cardiovascular diseases for men and women 45-74 years of age living in 76 communities in mid-Sweden were obtained from the National Bureau of Statistics. After age standardization, the rates for mortality from all causes and cardiovascular mortality were substantially higher in the Westernmost communities compared with those in the East, whereas for non-cardiovascular mortality there were no systematic differences. The county with the higher rate for IHD had a 60% higher rate for men aged 45-64 years and a 53% higher rate for women aged 45-64 years than the county with the lowest rate. The corresponding excess mortality rates from stroke were 73% for men aged 45-74 and 46% for women aged 45-74 years. The cause of this variation is not known. It is not due to the confounding effect of different age distributions in the communities, differences in the registration of causes of death, or differences in case fatality rate.
More Related Videos
04:41Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
Published on: July 3, 2018
14:35Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
Published on: April 17, 2021
Related Concept Videos
Ischemic Heart Disease: Overview
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...
Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
Myocarditis I: Introduction
Coronary Artery Disease III: Clinical Manifestations