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Updated: Jun 16, 2026
Rodent Model of Intestinal Ischemia-Reperfusion Injury via Occlusion of the Superior Mesenteric Artery
Published on: October 20, 2023
[Damage control surgery for acute mesenteric ischemia]
Jian-Feng Gong1, Wei-Ming Zhu, Xing-Jiang Wu
1Department of General Surgery, Jinling Hospital, Nanjing 200000, China.
Objective:
To examine the outcome of damage control surgery (DCS) in patients with acute mesenteric ischemia (AMI).
Methods:
Clinical data of 15 consecutive AMI cases treated with DCS from May 2001 to March 2009 at the Research Institute of General Surgery, Jinling Hospital were retrospectively analyzed. Eleven patients had acute superior mesenteric vein thrombosis (MVT) on admission, and 4 suffered from acute mesenteric arterial embolism/thrombosis (MAE/MAT). The staged damage control approach included immediate resection of the involved bowel (but no attempts to restore gastrointestinal continuity), open thrombectomy, transfer of the patients to ICU for resuscitation, and thrombolysis prior to the planned definitive reconstructive procedure.
Results:
Of 15 patients, 10 (66.7%) survived. The mean remnant small bowel length was (209.0+/-53.8) cm (120 to 280 cm). None of the survived patients was parenteral nutrition-dependent. Of the 5 deaths, 2 died of recurrence of thrombosis and necrosis of the remaining bowel,1 of massive gastrointestinal bleeding. One patient abandoned treatment intra-operatively, and another with total small bowel resection abandoned treatment postoperatively.
Conclusions:
Damage control approach improves the survival of patients with AMI. Thrombectomy and thrombolysis are necessary for AMI management to prevent progression or further development of the thrombosis.
Insights
Damage control surgery (DCS) significantly improves survival rates for acute mesenteric ischemia (AMI) patients. Early thrombectomy and thrombolysis are crucial for managing AMI and preventing thrombosis progression.
Area of Science:
- Gastroenterology
- Surgical Innovation
- Vascular Surgery
Context:
- Acute mesenteric ischemia (AMI) presents a critical surgical challenge with high mortality.
- Damage control surgery (DCS) offers a staged approach for managing complex abdominal catastrophes.
- This study evaluates DCS in a cohort of patients with acute mesenteric ischemia.
Purpose:
- To assess the efficacy and outcomes of damage control surgery (DCS) in patients diagnosed with acute mesenteric ischemia (AMI).
- To analyze the impact of thrombectomy and thrombolysis within the DCS framework for AMI.
- To determine survival rates and identify factors influencing outcomes in AMI patients undergoing DCS.
Summary:
- A retrospective analysis of 15 acute mesenteric ischemia (AMI) patients treated with damage control surgery (DCS) was conducted.
- The staged DCS approach involved bowel resection, thrombectomy, ICU resuscitation, and thrombolysis before definitive reconstruction.
- Survival rate was 66.7% (10 out of 15), with no parenteral nutrition dependence among survivors. Key interventions included thrombectomy and thrombolysis.
Impact:
- Damage control surgery (DCS) demonstrates a positive impact on survival for acute mesenteric ischemia (AMI) patients.
- The findings underscore the importance of thrombectomy and thrombolysis in preventing disease progression.
- This approach offers a viable strategy for managing severe AMI, potentially improving patient outcomes.
