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Asymmetrical Flow Field-Flow Fractionation for Sizing of Gold Nanoparticles in Suspension
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Published on: September 11, 2020

Application of gold nanoparticles in separation sciences.

David Sýkora1, Václav Kasicka, Ivan Miksík

  • 1Department of Analytical Chemistry, Institute of Chemical Technology, Prague, Czech Republic.

Journal of Separation Science
|January 26, 2010
PubMed
Summary

Gold nanoparticles (GNPs) are versatile tools in separation sciences, enhancing techniques like chromatography and electrophoresis. Their use spans various analyte sizes and includes advanced sample preparation for complex matrices.

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Area of Science:

  • Separation Science
  • Nanotechnology
  • Analytical Chemistry

Background:

  • Gold nanoparticles (GNPs) offer unique properties for analytical applications.
  • Separation sciences benefit from nanomaterial integration for enhanced performance.
  • Characterization of nanoparticles is crucial for reliable application.

Purpose of the Study:

  • To review the applications of gold nanoparticles (GNPs) in separation sciences.
  • To classify GNP applications based on analyte molecular size and separation techniques.
  • To highlight recent advances in sample preparation using GNPs.

Main Methods:

  • Review of literature on gold nanoparticle applications in electromigration and chromatographic techniques.
  • Classification of applications in capillary electrophoresis (CE), microchip CE, MEKC, CEC, HPLC, and GC.
  • Discussion of GNPs in sample preparation, preconcentration, and preseparation.
  • Overview of GNP preparation, modification, and characterization methods.

Main Results:

  • GNPs are effectively utilized across various separation methods including CE, HPLC, and GC.
  • Applications are categorized by analyte size, from small molecules to biopolymers like proteins and nucleic acids.
  • Recent advancements show promise for GNPs in sample preparation and preconcentration from complex samples.

Conclusions:

  • Gold nanoparticles demonstrate significant potential and versatility in modern separation sciences.
  • GNP integration offers improved analytical capabilities for diverse analytes and matrices.
  • Further research into GNP preparation and application can drive innovation in analytical chemistry.