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Depression: Overview

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...

Depressive Disorders: Etiology

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
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Long-term Depression

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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.

Long-term Depression

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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Depressive Disorders: MDD and Dysthymia

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Benefits of Self-Esteem

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Related Experiment Video

Updated: Jun 16, 2026

A New Method for Inducing a Depression-Like Behavior in Rats

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

Quality of Web-based information on depression.

Ariane Zermatten¹, Yasser Khazaal, Olivier Coquard

¹Depression Program, Department of Psychiatry, Geneva University Hospitals, Belle-ideé, 2 ch. Du Petit Bel-Air, Chêne Bourg, Geneva, Switzerland. Ariane.Zermatten@hcuge.ch

Depression and Anxiety

|January 26, 2010

Summary

Current depression websites generally offer good quality, with higher scores for accountability and content when featuring the Health on the Net (HON) label or a high Brief DISCERN score.

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Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Published on: April 26, 2024

Area of Science:

Digital Health
Health Informatics
Mental Health Online Resources

Background:

Previous website quality studies on depression are outdated and focused narrowly on content.
Current research is needed to assess contemporary depression websites using multiple quality indicators.

Purpose of the Study:

To evaluate the quality of current online resources for depression.
To assess websites using indicators like accountability, interactivity, aesthetics, readability, and content quality.

Main Methods:

Searched popular search engines using depression-related keywords.
Evaluated 45 websites on accountability, interactivity, aesthetics, readability, and content quality.
Assessed for Health on the Net (HON) label, website affiliation, and used Brief DISCERN for consumer content quality assessment.

Main Results:

Depression websites demonstrated good content quality.
Websites with the HON label showed significantly higher accountability, content quality, and Brief DISCERN scores.
Positive correlations were found between content quality, Brief DISCERN, HON label, and website affiliation.

Conclusions:

The overall quality of websites addressing depression is considered good.
The Health on the Net (HON) certification and high Brief DISCERN scores are indicators of superior website quality for depression information.