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Related Concept Videos

Antiprotozoal Agents01:21

Antiprotozoal Agents

Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...
Trichomoniasis01:18

Trichomoniasis

Trichomonas vaginalis is a flagellated protozoan parasite and the causative agent of trichomoniasis, one of the most prevalent non-viral sexually transmitted infections in the United States. This extracellular parasite primarily colonizes the lower genitourinary tract in women—particularly the vagina—and in men, the urethra and prostate. Its structural and functional adaptations enable its survival, motility, and pathogenicity within the host environment.Structural Features and Host EntryT.
Antibiotic Selection00:57

Antibiotic Selection

Overview
Dosage Regimen: Fixed Dose01:01

Dosage Regimen: Fixed Dose

Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
Toxoplasmosis01:28

Toxoplasmosis

Toxoplasmosis, a zoonotic disease caused by the protozoan Toxoplasma gondii, poses significant public health challenges globally due to its high seroprevalence and varied clinical manifestations. As an obligate intracellular parasite, T. gondii can infect all warm-blooded vertebrates, but felids are its only definitive hosts, shedding unsporulated oocysts into the environment. Humans typically acquire the infection through ingestion of tissue cysts in undercooked meat or oocysts from...
Dosage Regimen: Multiple Oral Dosage01:25

Dosage Regimen: Multiple Oral Dosage

Understanding how a drug's concentration fluctuates within the body over time is crucial in pharmacokinetics, particularly with multiple oral doses. A graphical representation of multiple oral dosages provides insight into these dynamics. Typical accumulation curves of a drug's concentration in the body reveal a sawtooth pattern, indicating periodic peaks and troughs correlating with each dose administration and the drug's subsequent elimination.The plasma concentration at any time during an...

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Related Experiment Video

Updated: Jun 16, 2026

Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds
10:49

Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds

Published on: August 21, 2021

[Doxycycline].

O Aupee1, D Almeras, P Le Garlantezec

  • 1Service de pharmacie, Hôpital d'Instruction des Armées du Val-de-Grâce, Paris. olivier.aupee@santarm.fr

Medecine Tropicale : Revue Du Corps De Sante Colonial
|January 27, 2010
PubMed
Summary
This summary is machine-generated.

Doxycycline is a versatile antibiotic effective against numerous bacterial infections and beneficial for malaria prevention. While generally well-tolerated, it has specific contraindications for children and pregnant or breastfeeding women.

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In vivo Application of the REMOTE-control System for the Manipulation of Endogenous Gene Expression
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Efficient Transcriptionally Controlled Plasmid Expression System for Investigation of the Stability of mRNA Transcripts in Primary Alveolar Epithelial Cells

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Last Updated: Jun 16, 2026

Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds
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Published on: August 21, 2021

In vivo Application of the REMOTE-control System for the Manipulation of Endogenous Gene Expression
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In vivo Application of the REMOTE-control System for the Manipulation of Endogenous Gene Expression

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Efficient Transcriptionally Controlled Plasmid Expression System for Investigation of the Stability of mRNA Transcripts in Primary Alveolar Epithelial Cells
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Efficient Transcriptionally Controlled Plasmid Expression System for Investigation of the Stability of mRNA Transcripts in Primary Alveolar Epithelial Cells

Published on: March 6, 2020

Area of Science:

  • Pharmacology and Microbiology
  • Antibiotic Therapy

Context:

  • Doxycycline, a semi-synthetic tetracycline derivative, possesses a favorable pharmacokinetic profile.
  • It exhibits broad-spectrum bacteriostatic activity and anti-inflammatory properties.
  • Bacterial resistance to doxycycline is primarily acquired.

Purpose:

  • To review the therapeutic applications, pharmacokinetic properties, and safety profile of doxycycline.
  • To highlight its efficacy in treating a wide range of infectious diseases and dermatological conditions.
  • To discuss its role in malaria prophylaxis.

Summary:

  • Doxycycline is indicated for brucellosis, pasteurellosis, borreliosis, rickettsioses, trepanomatosis, cholera, leptospirosis, Q fever, Chlamydia/Mycoplasma infections, gonococcal infections, and anthrax.
  • It is also used for acne and rosacea treatment and malaria prophylaxis due to its effect on Plasmodium development.
  • Adverse effects like gastrointestinal upset are common but manageable with new formulations; phototoxicity is dose-dependent.

Impact:

  • Doxycycline offers a valuable treatment option for various bacterial and protozoal infections.
  • Its utility extends to dermatological conditions and preventative medicine (malaria).
  • Understanding its contraindications, particularly in pediatric and obstetric populations, is crucial for safe usage.