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Related Experiment Videos

Artificial endometrial stimulation for frozen embryo replacement.

K A Jaroudi1, C J Hamilton, W N Willemsen

  • 1Department of Obstetrics and Gynaecology, King Faisal Specialist Hospital and Research Centre Riyadh, Saudi Arabia.

Fertility and Sterility
|April 1, 1991
PubMed
Summary

This study on frozen embryo transfer used hormone therapy for endometrial preparation, achieving three pregnancies from fourteen transfers. This method offers cycle control and reduces cancellations due to ovulation issues.

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Area of Science:

  • Reproductive Endocrinology
  • Embryology
  • In Vitro Fertilization

Background:

  • Endometrial preparation is crucial for successful embryo implantation.
  • Ovulatory dysfunction can lead to cycle cancellations in fertility treatments.
  • Hormonal protocols offer potential for improved cycle control.

Purpose of the Study:

  • To evaluate a uniform hormonal protocol for endometrial preparation in frozen embryo transfer (FET) cycles.
  • To assess the efficacy of exogenous estrogen (E) and progesterone (P) in controlling the menstrual cycle for FET.
  • To determine pregnancy and implantation rates using this standardized FET protocol.

Main Methods:

  • Eighteen FET cycles were initiated.
  • A consistent protocol involving exogenous estrogen and progesterone was used for endometrial preparation.

Related Experiment Videos

  • Embryo division and replacement were performed in fourteen cycles.
  • Hormone (E and P) discontinuation timing post-embryo transfer (ET) was standardized.

    • Main Results:

    • The hormonal protocol successfully eliminated cycle cancellations due to ovulatory dysfunction, providing complete cycle control.
    • Fourteen cycles proceeded to embryo transfer, resulting in three pregnancies.
    • In the conception cycles, estrogen was stopped 12 days after ET, and progesterone was stopped 26 days after ET.
    • One pregnancy resulted in an early abortion (6 weeks gestation); the other two progressed to the third trimester.

    Conclusions:

    • A uniform exogenous hormonal protocol for endometrial preparation in FET cycles provides excellent cycle control.
    • This FET protocol resulted in a clinical pregnancy rate of 21.4% (3/14) in cycles with embryo transfer.
    • Further research may optimize hormone discontinuation timing to improve ongoing pregnancy rates.