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Related Concept Videos

Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
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Cell-mediated Immune Responses

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Related Experiment Video

Updated: Jun 16, 2026

Murine Full-thickness Skin Transplantation
07:59

Murine Full-thickness Skin Transplantation

Published on: January 2, 2017

Cutaneous cryptococcosis in solid organ transplant recipients.

Hsin-Yun Sun1, Barbara D Alexander, Olivier Lortholary

  • 1VA Pittsburgh Healthcare System, University Drive C, Pittsburgh, PA 15240, USA.

Medical Mycology
|January 27, 2010
PubMed
Summary

Cutaneous cryptococcosis in solid organ transplant recipients often indicates disseminated disease, primarily affecting the extremities. Management outcomes were similar for localized and disseminated forms, with mortality linked to renal failure and delayed onset.

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Last Updated: Jun 16, 2026

Murine Full-thickness Skin Transplantation
07:59

Murine Full-thickness Skin Transplantation

Published on: January 2, 2017

Area of Science:

  • Infectious Diseases
  • Transplantation Medicine
  • Dermatology

Background:

  • Cutaneous cryptococcosis in solid organ transplant (SOT) recipients is not well-defined.
  • Understanding its clinical course is crucial for patient management.

Purpose of the Study:

  • To describe the clinical manifestations, antifungal therapy, and outcomes of cutaneous cryptococcosis in SOT recipients.
  • To identify factors associated with mortality in these patients.

Main Methods:

  • Prospective cohort study of 146 SOT recipients with cryptococcosis.
  • Detailed analysis of 26 patients with documented cutaneous cryptococcosis, including presentation, treatment, and outcomes.
  • Comparison of outcomes between localized and disseminated disease, and factors associated with mortality.

Main Results:

  • Cutaneous cryptococcosis occurred in 17.8% of SOT recipients with cryptococcosis, manifesting as various skin lesions, predominantly on lower extremities.
  • Disseminated disease (69.2%) involved central nervous system, lungs, or bloodstream; localized disease occurred in 30.8%.
  • Mortality at 90 days was 15.4%, with no significant difference between localized and disseminated disease. Renal failure, longer time to onset post-transplant, and abnormal mental status were associated with death.

Conclusions:

  • Cutaneous cryptococcosis in SOT recipients frequently signifies disseminated infection, often affecting extremities.
  • Appropriate antifungal management yields comparable outcomes for localized and disseminated cutaneous cryptococcosis.
  • Identifying risk factors like renal failure is vital for improving survival rates in SOT recipients with this infection.