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Measuring Lactase Enzymatic Activity in the Teaching Lab
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Characterisation and functionality of inhalation anhydrous lactose.

Chonladda Pitchayajittipong1, Robert Price, Jagdeep Shur

  • 1Pharmaceutical Surface Science Research Group, School of Pharmacy and Pharmacology, University of Bath, Bath, UK.

International Journal of Pharmaceutics
|January 27, 2010
PubMed
Summary
This summary is machine-generated.

Dry powder inhaler (DPI) performance depends on lactose properties. Higher powder fluidization energy in lactose excipients correlated with improved budesonide fine particle dose delivery in DPI formulations.

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Area of Science:

  • Pharmaceutical Technology
  • Materials Science

Background:

  • Dry powder inhalers (DPIs) are crucial for respiratory drug delivery.
  • Lactose is a common excipient in DPI formulations, influencing drug aerosolization.
  • Understanding excipient properties is key to optimizing DPI performance.

Purpose of the Study:

  • To investigate the relationship between physicochemical properties of anhydrous and monohydrate lactose grades and their impact on DPI performance.
  • To compare the aerosolization characteristics of different lactose grades when used with budesonide in DPI formulations.

Main Methods:

  • Characterization of lactose excipients using particle size analysis, moisture sorption, and powder rheometry.
  • Formulation of capsule-based DPIs containing budesonide (200 µg) and various lactose grades.
  • Evaluation of aerosolization performance using inertial impaction measurements.

Main Results:

  • Inhalation anhydrous lactose grades were readily characterizable.
  • Fine particle doses of budesonide ranged from 24 to 49 µg across different lactose formulations.
  • No direct correlation was found between aerosolization performance and particle size or powder density.
  • A positive correlation was observed between higher powder fluidization energy of lactose grades and increased budesonide fine particle dose.

Conclusions:

  • Powder fluidization energy is a critical physicochemical property of lactose excipients influencing DPI aerosolization.
  • Lactose grades with higher fluidization energy can enhance fine particle drug delivery in DPIs.
  • These findings provide valuable insights for selecting optimal lactose excipients for improved DPI formulation development.