Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Multiple Sclerosis l: Introduction

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

Myasthenia Gravis: Overview and Treatment

Myasthenia Gravis: Overview and Treatment

Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which leads...

Muscle Recovery and Fatigue

Muscle Recovery and Fatigue

Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective response...

Myasthenia Gravis ll: Pathophysiology

Myasthenia Gravis ll: Pathophysiology

The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...

Myocarditis IV: Nursing Management

Myocarditis IV: Nursing Management

Myocarditis is an inflammatory condition of the myocardium requiring meticulous nursing management for optimal patient outcomes. Effective management begins with a thorough assessment of the patient's medical history, paying close attention to past infections, autoimmune disorders, travel history, and exposure to toxins or drugs. Recent viral infections and systemic diseases are particularly relevant due to their potential role in triggering myocarditis.Physical Examination and MonitoringThe...

Fatigue

Fatigue

Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Accuracy of heart rate measurement using AirPods Pro 3 during graded treadmill exercise: A laboratory-based validation study.

PLOS digital health·2026

Same author

Memories of Mark. Personal reflections by those in IFCN who worked with Mark Hallett.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2026

Same author

A genome-scale single-cell CRISPRi map of trans gene regulation across human pluripotent stem cell lines.

Cell genomics·2025

Same author

Accounting for inconclusive results and repeated testing: A framework for evaluating wearable electrocardiogram diagnostic performance with application to Apple Watch and artificial intelligence-enhanced interpretation.

Heart rhythm·2025

Same author

Lipid-lowering therapy treatment regimens in high- and very high-risk patients for the prevention of cardiovascular events: results from the Irish cohort of the multinational, observational SANTORINI study.

Irish journal of medical science·2025

Same author

Bilateral subdural hygromas following dural puncture.

BMJ case reports·2025

Search research articles

Related Experiment Video

Updated: Jun 16, 2026

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Published on: February 20, 2020

Fatigue in multiple sclerosis: mechanisms and management.

Steve Vucic¹, David Burke, Matthew C Kiernan

¹Department of Neurology, Westmead Hospital and Western Clinical School, University of Sydney, Sydney, NSW, Australia.

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology

|January 27, 2010

Summary

Multiple sclerosis fatigue stems from nerve signal disruptions. Restoring normal nerve conduction may alleviate fatigue and prevent further nerve damage in MS patients.

More Related Videos

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

Published on: May 31, 2016

Related Experiment Videos

Last Updated: Jun 16, 2026

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Published on: February 20, 2020

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

Published on: May 31, 2016

Area of Science:

Neuroscience
Immunology
Neurology

Background:

Multiple sclerosis (MS) is a chronic, immune-mediated central nervous system (CNS) disorder.
Fatigue is a common and debilitating symptom in MS, significantly impacting quality of life.
Fatigue in MS is exacerbated by activity and heat, and linked to reduced muscle activation.

Purpose of the Study:

To explore the mechanisms underlying fatigue in multiple sclerosis.
To investigate the role of axonal demyelination and conduction block in MS-related fatigue.
To evaluate potential therapeutic strategies for MS fatigue and neuroprotection.

Main Methods:

Review of evidence linking central mechanisms to fatigue in MS.
Examination of activity-dependent conduction block (ADCB) in demyelinated axons.
Analysis of Na+/K+ pump dysfunction and its effects on axonal conduction.

Main Results:

Fatigue in MS is strongly associated with reduced voluntary muscle activation.
Activity-dependent conduction block (ADCB) in demyelinated axons, due to hyperpolarization and Na+/K+ pump dysfunction, contributes to MS fatigue.
These processes can lead to axonal degeneration via calcium overload.

Conclusions:

Axonal conduction block, driven by Na+/K+ pump activity and demyelination, is a key mechanism of MS fatigue.
Selective channel blockers show promise in restoring normal conduction, improving fatigue, and potentially preventing axonal degeneration.
Targeting conduction abnormalities offers a neuroprotective strategy for MS patients.