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Updated: Jun 16, 2026

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
Published on: September 30, 2016
Is tailored adjuvant treatment for colon cancer possible?
Marc Van den Eynde1, Ahmad Awada, Alain Hendlisz
1Department of Medicine, Institut Jules Bordet, Université Libre de Bruxelles, Belgium. marc.vandeneynde@hotmail.com
Abstract:
High-risk stage II and stage III colon cancers are associated with significant recurrence rates after surgical resection. Adjuvant chemotherapy has demonstrated a significant disease-free and overall survival benefit for patients, even if not helpful for all. Currently, there are limited clinical and molecular markers that can predict response to chemotherapy and clinical outcome in advanced colon cancer. Herein, we review and discuss recent data about the most promising clinicopathologic and molecular factors described thus far and that are of interest in the management of patients with colon cancer.
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