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Use of a homeopathic preparation for "infantile colic" and an apparent life-threatening event
Shraga Aviner1, Matitiahu Berkovitch, Hedva Dalkian
1Barzilai Medical Center, Department of Pediatrics, 2 Hahistadrut St, Ashkelon 78278, Israel. aviners@barzi.health.gov.il
Insights
Homeopathic Gali-col Baby ingestion was linked to apparent life-threatening events (ALTE) in infants. Further research and regulation are needed to ensure the safety of homeopathic products for children.
Area of Science:
- Pediatric Medicine
- Toxicology
- Homeopathy Research
Background:
- Apparent life-threatening events (ALTE) in infants are rare when caused by drug or toxin ingestion.
- Homeopathic medications have not been previously implicated in infant ALTE.
Purpose of the Study:
- To investigate a potential association between Gali-col Baby, a homeopathic agent for infantile colic, and ALTE in infants.
- To identify the safety profile of Gali-col Baby in pediatric populations.
Main Methods:
- A retrospective case-control study was conducted at Barzilai Medical Center from January 2005 to August 2008.
- Infants under 1 year admitted with ALTE were compared to age-matched controls admitted for other reasons.
- Medication history prior to admission was reviewed for all participants.
Main Results:
- Eleven out of 115 infants admitted for ALTE had ingested Gali-col Baby, compared to none in the control group (P < .005).
- Three infants experienced significant Gali-col Baby overdose.
- No other causes for ALTE were identified in the affected infants.
Conclusions:
- Gali-col Baby is associated with ALTE in some infants.
- Controlled trials on the efficacy and safety of Gali-col Baby are lacking.
- Improved regulation and oversight of homeopathic medications like Gali-col Baby are necessary to prevent adverse events.
Objective:
An apparent life-threatening event (ALTE) caused by ingestion of drugs or toxins has been reported rarely among infants. None of these agents was homeopathic medication. We report 11 infants who presented with an ALTE after ingestion of Gali-col Baby, a homeopathic agent indicated for "infantile colic."
Methods:
A retrospective case-control study was conducted. Charts of all infants who were younger than 1 year and were admitted with an ALTE from January 2005 through August 2008 to the pediatric division at the Barzilai Medical Center were reviewed. Age-matched infants who were admitted on the same dates for a reason other than ALTE served as a control group. Information on medications administered before admission was recorded.
Results:
During the study period, 36 635 children visited the pediatric emergency department of the Barzilai Medical Center. There were 11 057 admissions to the pediatric division during this period, 115 of which were because of an ALTE. Eleven of these infants received Gali-col Baby before the event as opposed to none in the control group (P < .005). Three infants received a significant overdose, compared with the manufacturer's recommended dosage. After a thorough investigation, no other presumptive causes for ALTE were found among the 11 infants.
Conclusions:
Gali-col Baby is associated with an ALTE in some infants. There are no published controlled trials on the efficacy or safety of its use; therefore, better control and supervision of Gali-col Baby and probably other homeopathic medications are needed to prevent possible serious adverse effects.
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