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Related Experiment Video

Updated: Jun 16, 2026

Intraportal Transplantation of Pancreatic Islets in Mouse Model

Intraportal Transplantation of Pancreatic Islets in Mouse Model

Published on: May 5, 2018

Bone marrow cell cotransplantation with islets improves their vascularization and function.

Naoaki Sakata¹, Nathaniel K Chan, John Chrisler

¹Department of Pediatrics, Islet Transplant Laboratory, Loma Linda University School of Medicine, CA, USA.

Transplantation

|January 27, 2010

Summary

This summary is machine-generated.

Cotransplanting bone marrow cells with islets enhances blood vessel formation around the islet graft, improving its function in diabetic mice. This approach shows promise for better islet transplantation outcomes.

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Area of Science:

Regenerative Medicine
Transplantation Biology
Vascular Biology

Background:

Islet transplantation is a potential therapy for type 1 diabetes.
Enhancing islet graft vascularization is crucial for successful transplantation.
Bone marrow cells possess angiogenic properties.

Purpose of the Study:

To investigate the angiogenesis-promoting effects of cotransplanting bone marrow cells with islets.
To evaluate the impact of this combined transplantation on islet graft vascularization and function.

Main Methods:

Streptozotocin-induced diabetic mice received islet-only, bone marrow-only, or islet plus bone marrow cell transplants.
Blood glucose, serum insulin, and glucose tolerance were monitored post-transplantation.
Histological analysis assessed vascularization (von Willebrand factor, VEGF) and islet-related markers (insulin, PDX-1).

Main Results:

The islet plus bone marrow group exhibited lower blood glucose and higher serum insulin levels.
Significantly enhanced peri-islet vascularization was observed in the combined transplant group.
Vascular endothelial growth factor (VEGF) staining was more prominent in bone marrow cells, and PDX-1 expression increased over time.

Conclusions:

Cotransplantation of bone marrow cells with islets promotes angiogenesis.
This enhanced vascularization improves islet graft function and survival.
Bone marrow cells contribute to islet graft vascularization and may possess endocrine potential.