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Related Experiment Video

Updated: Jun 16, 2026

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

Published on: August 25, 2021

Myc proteins as therapeutic targets.

W C Gustafson¹, W A Weiss

¹Department of Pediatrics, University of California, San Francisco, CA 94158-9001, USA. GustafsonC@peds.ucsf.edu

|January 27, 2010

Summary

Myc proteins are crucial in cancer progression. Targeting Mycn, amplified in aggressive neuroblastoma, offers new therapeutic strategies for this childhood cancer.

Area of Science:

Oncology
Molecular Biology
Pediatric Cancer Research

Background:

Myc proteins (c-myc, Mycn, Mycl) regulate cell proliferation and apoptosis, critical in cancer development.
MYCN gene amplification is a key marker for aggressive, treatment-resistant neuroblastoma in children.
Myc protein stability, influenced by phosphorylation and ubiquitination, presents therapeutic targets.

Purpose of the Study:

To review the function and regulation of Myc proteins in neuroblastoma.
To discuss emerging therapeutic strategies targeting Mycn in neuroblastoma.

Main Methods:

Literature review of Myc protein function, regulation, and therapeutic targeting in neuroblastoma.
Analysis of signaling pathways involved in Myc regulation, including RTK/PI3K/Akt/mTOR and Aurora A kinase.

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An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells

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Published on: May 21, 2019

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Last Updated: Jun 16, 2026

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

Published on: August 25, 2021

An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells

An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells

Published on: May 21, 2019

Examination of Myc's role in apoptosis via the p53/Mdm2/Arf pathway and p53 mutations in relapsed neuroblastoma.

Main Results:

Myc proteins are central to neuroblastoma's aggressive nature and refractoriness to chemotherapy.
Phosphorylation and ubiquitin-mediated modulation of Myc proteins are key regulatory mechanisms.
Interactions with the p53 pathway, often mutated in relapsed neuroblastoma, contribute to therapeutic resistance.

Conclusions:

Understanding Myc protein regulation is vital for developing effective neuroblastoma treatments.
Targeting Mycn and its associated pathways holds promise for overcoming chemotherapy resistance in pediatric neuroblastoma.