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Clear cell sarcoma: a case mimicking primary cutaneous malignant melanoma.
M Rodríguez-Martín1, M Sáez-Rodríguez, B Esquivel
1Department of Dermatology, Hospital Universitario de Canarias, University of La Laguna, 38320 - La Laguna, Tenerife, Spain. marinarm@gmail.com
Indian Journal of Dermatology
|January 27, 2010
Summary
Clear cell sarcoma (CCS) is a rare soft tissue cancer. Early recognition and surgical removal are crucial for a favorable prognosis in clear cell sarcoma patients.
Area of Science:
- Oncology
- Surgical Pathology
- Genetics
Background:
- Clear cell sarcoma (CCS) is a distinct soft tissue sarcoma variant.
- It exhibits clear cells resembling those in clear cell melanoma.
- First described by Dr. Franz M. Erzinger, CCS typically affects deeper soft tissues near fascia, tendons, or aponeuroses.
Purpose of the Study:
- To describe an unusual case of clear cell sarcoma.
- To highlight the importance of early diagnosis and treatment for this rare sarcoma.
Main Methods:
- Histopathological examination of the neoplasm.
- Review of clinical presentation and patient history.
- Consideration of characteristic genetic translocation t(12;22) (q13;q12).
Main Results:
- The patient presented with an unusual neoplasm mimicking malignant melanoma.
- Clear cell sarcoma is characterized by prominent clear cells.
- The translocation t(12;22) (q13;q12) is considered pathognomonic for CCS.
Conclusions:
- Clear cell sarcoma requires early recognition and radical surgical intervention for optimal outcomes.
- Tumor size is a significant prognostic factor in CCS.
- Prompt diagnosis is essential for effective management of clear cell sarcoma.
