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Cytogenetic effects of quinalphos in mice
Summary
Quinalphos exposure caused genetic damage in mice, evidenced by increased micronuclei and chromosomal aberrations in bone marrow and germ cells. Sperm abnormalities were also observed, indicating potential reproductive toxicity.
Area of Science:
- Toxicology
- Genetics
- Environmental Health
Background:
- Pesticides like quinalphos are widely used in agriculture.
- Understanding the toxicological profile of pesticides is crucial for public health and environmental safety.
Purpose of the Study:
- To investigate the cytogenetic effects of quinalphos exposure in Swiss albino mice.
- To evaluate the potential for quinalphos to induce genotoxicity and reproductive harm.
Main Methods:
- Swiss albino mice were administered quinalphos orally at doses of 5, 10, and 15 mg/kg body weight.
- Cytogenetic damage was assessed using the micronucleus test, bone marrow and germ cell chromosome assays, and sperm morphology assay.
Main Results:
- Quinalphos significantly increased micronuclei in bone marrow cells.
- Chromosomal aberrations were elevated in bone marrow cells (at 10 and 15 mg/kg) and germ cells (at all doses).
- A high incidence of abnormal sperm was observed in treated mice.
Conclusions:
- Quinalphos exhibits significant genotoxic effects in mammals.
- The findings suggest potential risks associated with quinalphos exposure, including reproductive toxicity.
