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Related Concept Videos

Voltage-gated Ion Channels01:26

Voltage-gated Ion Channels

Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several types of...
Voltage-gated Ion Channels01:26

Voltage-gated Ion Channels

Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several types of...
Non-gated Ion Channels01:24

Non-gated Ion Channels

Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism.
Non-gated Ion Channels01:24

Non-gated Ion Channels

Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism.
Nociception01:44

Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...

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Related Experiment Video

Updated: Jun 16, 2026

Patch Clamp Recordings on Intact Dorsal Root Ganglia from Adult Rats
12:00

Patch Clamp Recordings on Intact Dorsal Root Ganglia from Adult Rats

Published on: September 29, 2016

Sodium channelopathies and pain.

Angelika Lampert1, Andrias O O'Reilly, Peter Reeh

  • 1Department of Physiology and Pathophysiology, Friedrich-Alexander University Erlangen-Nuremberg, Universitätsstrasse 17, 91054, Erlangen, Germany. Lampert@physiologie1.uni-erlangen.de

Pflugers Archiv : European Journal of Physiology
|January 27, 2010
PubMed
Summary
This summary is machine-generated.

Voltage-gated sodium channels, Nav1.7 and Nav1.8, are crucial for pain signaling. Mutations in Nav1.7 cause heritable pain syndromes by altering nociceptor electrogenesis.

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Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats
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Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats

Published on: January 21, 2020

Related Experiment Videos

Last Updated: Jun 16, 2026

Patch Clamp Recordings on Intact Dorsal Root Ganglia from Adult Rats
12:00

Patch Clamp Recordings on Intact Dorsal Root Ganglia from Adult Rats

Published on: September 29, 2016

Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats
07:12

Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats

Published on: January 21, 2020

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Chronic pain affects 10% of the global population, with many patients unresponsive to current treatments.
  • Nociceptors transmit pain signals to the CNS via action potentials, mediated by voltage-gated sodium channels (Nav channels).
  • Nav1.7 and Nav1.8 subunits are key in peripheral pain processing and heightened pain sensitivity.

Purpose of the Study:

  • To review recent advances in understanding how Nav1.7 mutations lead to abnormal nociceptor electrogenesis.
  • To summarize the role of Nav1.8 in peripheral pain.
  • To discuss other sodium channelopathies linked to pain disorders.

Main Methods:

  • Review of recent scientific literature on Nav channel function and pain.
  • Analysis of biophysical properties of mutant Nav1.7 channels.
  • Examination of the role of Nav1.8 in pain pathways.

Main Results:

  • Mutations in the SCN9A gene (encoding Nav1.7) are linked to heritable pain syndromes.
  • Aberrant electrogenesis of nociceptors results from biophysical changes in mutant Nav1.7.
  • Nav1.8 plays a significant role in peripheral pain processing.

Conclusions:

  • Nav1.7 and Nav1.8 are critical targets for understanding and treating chronic pain.
  • Further research into sodium channelopathies can reveal new therapeutic strategies for pain management.