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Updated: Jun 16, 2026
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Published on: June 29, 2013
Intramuscular fetal corticosteroid therapy short-term effect on maternal-fetal Doppler velocimetry
I Babović1, S Plesinac, J Opalić
1Institute for Gynecology and Obstetrics, Clinical Center of Serbia, Belgrade, Serbia. ivana.r.babovic@gmail.com
Aim:
The aim of the study was to assess the short-term effects of intramuscular (IM) corticosteroid therapy (CST) on fetoplacental and fetal circulation in high-risk pregnancies of preterm labor.
Method:
We evaluated the effect of IM fetal single-dose dexamethasone (4 mg/kg) on fetoplacental and fetal circulation two hours before and 0-4 hours after CST in 38 fetuses after the 32nd week of gestation.
Result:
Changes in the umbilical artery (UA) resistance index (RI) after fetal CST (AU RI1) were significantly correlated with gestational age after the 32nd week at recording r = 0.354; p < 0.05. There was a statistically significant difference of RI in the descending aorta (DAo) before and after therapy; p < 0.001 (-0.04-0.01), 95% confidence interval (CI) for differences.
Conclusion:
Short-time effects after fetal IM CST include an increased index resistance in DAO as well as decreased RI in UA after the 32nd week.
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