Chorionic villus sampling: analysis of the first 350 singleton pregnancies by a single operator

Area of Science:

• Perinatology
• Medical Genetics
• Obstetrics

Background:

• Prenatal genetic diagnosis is crucial for managing high-risk pregnancies.
• Chorionic villus sampling (CVS) is a widely used invasive prenatal diagnostic technique.

Purpose of the Study:

• To evaluate the success rate, safety, and reliability of chorionic villus sampling (CVS).
• To identify factors influencing CVS outcomes in prenatal genetic diagnosis.

Main Methods:

• Analysis of 350 chorionic villus sampling (CVS) cases (215 transabdominal, 135 transvaginal) performed between 9 and 32 gestational weeks.
• Data collected from an outpatient prenatal diagnosis and therapy laboratory at a university tertiary care center.

Main Results:

• The overall CVS sampling success rate was 98% (343/350), with most cases requiring one or two aspirations (92%).
• Fetal genotype analysis was the primary indication (45%).
• The overall fetal loss rate was 1.7% (6/350), and early bleeding complications occurred in 11.4% (40/350). Rates of PROM, preterm birth, and placental disorders were within expected ranges.

Conclusions:

• Chorionic villus sampling (CVS) demonstrates a high success rate and is a safe, reliable method for prenatal genetic diagnosis.
• The procedure's success and safety are significantly influenced by the experience of the performing personnel.