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Mixed gonadal dysgenesis in a 45,X neonate with chromosome Y material in the dysgenetic gonad

Ageliki Karatza1, Dionisios Chrysis, Eunice-Georgia Stefanou

  • 1Department of Pediatrics, University of Patras Medical School, Rio, Greece.

Journal of Pediatric Endocrinology & Metabolism : JPEM
|January 28, 2010
PubMed

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Evolution
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Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers.  Nondisjunction is common during anaphase I or anaphase II of meiosis.  Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold sister...
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Among mammals, the gender of an organism is determined by the sex chromosomes. Humans have two sex chromosomes, X and Y. Every human diploid cell has 22 pairs of autosomes and one pair of sex chromosomes. A human female has two X chromosomes, while a male has one X chromosome and one Y chromosome.
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